Stopping spyware (‘malware’) is more than a one-time inoculation, folks.
This is about a weekly habit of cleaning ‘nasty dust bunnies’
from your personal computer.
In much the same way you clean your home with your favorite broom
and your favorite cleaning solvents, you will also need excellent tools
to clean spyware out of your PC.
http://top5antispywarereviews.com

First of all Nod32 sucks. It’s detection rate is terrible, and I wouldn’t recommend anyone to use it.

In my honest opinion, you’re better of with a free antivirus like Avira AntiVir.
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The only good free antispyware I can recommend is Windows Defender. It includes an antimalware that will also prevent changes in your computer without your approval.

To enhance your security, you can also download Threatfire, which it’s a very odd security software, from threatfire.com. Threatfire detects behavioral malicious software. So what it does is that if you have a program that is making changes in your computer like a virus, spyware, or other type of malware would, it stops it. It’s not currently considered an anti-spyware, even though it uses the same database as Spyware Doctor, one of the world’s best antispywares, because they’re both from PC-Tools.

Also, if you’re currently using Windows Firewall. I would download Zone Alarm Firewall from zonealarm.com. The windows firewall is pretty weak and many vulnerabilities have been detected. Apparently they won’t be fixed for Windows XP nor Vista, but they’re not showing up in Windows 7.

So you can download these four or you can buy an Interent Security Suit. There are three good ones I know.

#1 Kaspersky Internet Security => It’s the best security suit made in the United States because it updates every single hour. It has everything you’ll need to keep your computer protected and it doesn’t use a lot of RAM, which it’s great.

#2 Panda Internet Security => It’s a pretty neat European Security Suit. I also has everything to keep your computer protected, but it might not be the best choice for old computers.

#3 Norton Internet Security => Norton used to suck. In 2009, their software was completely reprogrammed. It’s pretty decent in my opinion.

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To comment on other people’s answers.

Malwarebytes is NOT an antispyware. It’s an antimalware that has fantastic detection rates, but it will NOT protect you.

Avast is now rated the #2 free antivirus. It’s an ok software.

Spybot S&D sucks lol. It can be useful because it does some protection, but you need to manually update it every single day(it’s better every couple of hours) so its just too darn annoying to use.

I have never heard of SpywareRemover. Honestly, I’ve been working with software security for around 8 years now, and if it was any excellent I would have heard of it.

I’ve heard of SuperAntiSpyware. Haven’t really tried it so I’m not going to recommend it to you. But some people say it’s pretty excellent.

Go to http://www.spywareremoverdownloads.com
Download Spywareremover for free.
Not only does spywareRemover get rid of the malicious spyware & adware that have invaded your system, it also prevents infestations from reoccurring. SPYwareRemover will keep your computer’s performance at its best and it will protect your privacy and your identity.

To remove spyware,there are many solutions exist, all of them with their own strengths and weaknesses.
You had better install at least 2 antispyware
Top 5 anti-spywares reviews,comparisons and download links on
http://www.anti-spyware-center.com/
You can download and scan your computer for free.

I changed to Avast a few months ago, I have also got superantispyware and Malwarebytes. I recently changed to Comodo firewall which seems fine and I seem to boot up quicker. They are all free for personal use and I have had no distress with Viruses Trojans Hackers etc. I also use Windows Defender from the Microsoft site. It is safe to use two anti-spy harvest but never use more than one A/V as it can cause conflicts. You should run A/V and anti spy weekly. Hope this helps

Get SuperAntispyware from
http://www.superantispyware.com/
most probably tell a friend to download it for u !
install it on your PC and update it and run a full system Scan
its the best available there
Excellent Luck

Spybot – Search & End – really nice immunization feature, it has always been really excellent and is constantly updated

Malwarebytes Anti-Malware – Do not use it but its’ also highly rated.

Combofix – when nothing else will work. Only run in safe mode.

Visit the link here for your solution
Top three free antispyware software review:
http://www.gocomputertraining.com/free-antispyware-software.html

you mean equal to Nod32?
you can’t place 2 antivirus in one o.s

try comodo.
http://www.comodo.com/home/internet-security/antivirus.php

That depends on how you define “best”. Do you mean:

- Most features?
- Detects the most malware? (Force not have excellent features or be hard to use)
- Simplest to use?
- Best reputation?

… or some amalgamation of these?